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Thursday, 18-Jul-2013 23:24 Email | Share | Bookmark
Dealing with HIV-infected individuals along with antiretrovirals

Men and women infected with HIV reduced the risk of transmitting the virus to their sexual partners by taking oral antiretroviral medicines when their immune systems were relatively healthy, according to findings anal beads from a large-scale clinical study sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.The clinical trial, known as HPTN 052, was slated to end in 2015 but the findings are being released early as the result of a scheduled interim review of the study data by an independent data and safety monitoring board (DSMB).

The DSMB concluded that it was clear that use of antiretrovirals by HIV-infected individuals with relatively healthier immune systems substantially reduced transmission to their partners. The results are the first from a major randomized clinical trial to indicate that treating an HIV-infected individual can reduce the risk of sexual transmission of HIV to an uninfected partner.Previous data about the potential value of antiretrovirals in making HIV-infected individuals less infectious to their sexual love partners came largely from observational and epidemiological studies, said NIAID Director Anthony S. Fauci, M.D. This new finding convincingly demonstrates that treating the infected individual -- and doing so sooner rather than later -- can have a major impact on reducing HIV transmission.

Led by study chair Myron Cohen, M.D., director of the Institute for Global Health and Infectious Diseases at the University of North Carolina at Chapel Hill, HPTN 052 began in April 2005 and enrolled 1,763 couples, all at least 18 years of age. The vast majority of the couples (97 percent) were heterosexual, which precludes any definitive conclusions about effectiveness in men who have sex with men. The study was conducted at 13 sites in Botswana, Brazil, India, Kenya, Malawi, South Africa, Thailand, the United States and Zimbabwe.

The U.S. site collected only limited data because of difficulties enrolling participants into the study. However, data from one serodiscordant couple at the site was included in the DSMB's analysis. At the time of enrollment, the HIV-infected partners (890 men, 873 women) had CD4+ T-cell levels -- a key measure of immune system health -- between big dildos 350 and 550 cells per cubic millimeter (mm³) within 60 days of entering the study. The HIV-uninfected partners had tested negative for the virus within 14 days of entering the.ly he's deep inside you.Well, just because you've been with your current lover a lot longer than five dates, there's no reason why you can't build some healthy, sexual anticipation.

Put a bar on penetrative sex and oral sex for a certain number of days, and during that time have a series of mini-.ginalized groups, including injection drug users, men who have sex with men, and commercial sex workers, some of the most vulnerable to HIV and AIDS, and, often due to laws and stigma, among the most difficult to reach with prevention and treatment programs.And fighting the HIV epidemic takes money and investment in young people; nations must make a commitment to robust domestic and global funding for HIV and AIDS prevention and treatment and support youth leadership and engagement in the HIV/AIDS response. Young people have proven that they can and will lead the prevention revolution. World leaders must follow SexToysBrand their lead and support their efforts to achieve the goal of an AIDS-free generation.

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